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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDKL1
All Species:
16.06
Human Site:
Y286
Identified Species:
27.18
UniProt:
Q00532
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00532
NP_004187.2
357
41671
Y286
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
I
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100233
358
41783
Y287
E
Q
L
L
H
H
P
Y
F
E
N
I
R
E
I
Dog
Lupus familis
XP_851358
367
42581
Y287
E
Q
L
L
Q
H
P
Y
F
D
S
M
R
E
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8CEQ0
352
41005
L281
E
R
L
T
C
E
Q
L
L
Q
H
P
Y
F
D
Rat
Rattus norvegicus
Q66HE7
352
40881
L281
E
R
L
T
C
E
Q
L
L
Q
H
P
Y
F
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514378
352
40807
L281
A
R
L
T
C
E
Q
L
L
Q
L
P
Y
F
N
Chicken
Gallus gallus
P13863
303
34670
D236
P
D
V
E
S
L
Q
D
Y
K
N
T
F
P
K
Frog
Xenopus laevis
P35567
302
34487
Q235
W
P
E
V
E
S
L
Q
D
Y
K
N
S
F
P
Zebra Danio
Brachydanio rerio
Q6AXJ9
350
40792
L281
E
R
L
S
C
E
Q
L
L
E
Q
P
Y
F
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_608950
501
57855
Y397
E
K
L
T
K
H
S
Y
F
D
D
Y
I
A
K
Honey Bee
Apis mellifera
XP_394980
385
44993
Y311
E
Q
L
L
Q
H
L
Y
F
E
N
F
H
F
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_787618
363
41882
F288
Q
E
L
M
E
M
P
F
F
D
R
H
K
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
S227
L
G
T
P
N
E
Q
S
W
P
G
V
S
C
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
T227
M
G
T
P
Y
E
D
T
W
R
G
V
T
S
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.7
88.5
N.A.
88.8
88.2
N.A.
86.5
37.8
36.9
77
N.A.
43.1
53.2
N.A.
59.5
Protein Similarity:
100
N.A.
99.1
92.6
N.A.
92.7
93
N.A.
92.7
52.3
54.6
87.9
N.A.
54.6
69.6
N.A.
73
P-Site Identity:
100
N.A.
100
66.6
N.A.
13.3
13.3
N.A.
6.6
6.6
0
20
N.A.
33.3
60
N.A.
20
P-Site Similarity:
100
N.A.
100
86.6
N.A.
33.3
33.3
N.A.
20
26.6
6.6
26.6
N.A.
53.3
60
N.A.
66.6
Percent
Protein Identity:
N.A.
34.4
N.A.
33
N.A.
N.A.
Protein Similarity:
N.A.
54.3
N.A.
54.6
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
29
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
8
0
0
0
0
8
8
8
22
8
0
0
0
22
% D
% Glu:
58
8
8
8
15
43
0
0
0
29
0
0
0
22
0
% E
% Phe:
0
0
0
0
0
0
0
8
43
0
0
8
8
43
0
% F
% Gly:
0
15
0
0
0
0
0
0
0
0
15
0
0
8
0
% G
% His:
0
0
0
0
15
36
0
0
0
0
15
8
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
15
8
0
15
% I
% Lys:
0
8
0
0
8
0
0
0
0
8
8
0
8
0
22
% K
% Leu:
8
0
72
29
0
8
15
29
29
0
8
0
0
0
22
% L
% Met:
8
0
0
8
0
8
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
0
8
0
0
0
0
0
29
8
0
0
8
% N
% Pro:
8
8
0
15
0
0
29
0
0
8
0
29
0
8
8
% P
% Gln:
8
29
0
0
15
0
43
8
0
22
8
0
0
0
0
% Q
% Arg:
0
29
0
0
0
0
0
0
0
8
8
0
22
0
0
% R
% Ser:
0
0
0
8
8
8
8
8
0
0
8
0
15
8
0
% S
% Thr:
0
0
15
29
0
0
0
8
0
0
0
8
8
0
8
% T
% Val:
0
0
8
8
0
0
0
0
0
0
0
15
0
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
36
8
8
0
8
29
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _